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FIGURE 5 In the early 2000s, the three-dimensional structures of small microcrystalline proteins (Zech et al., 2005), short peptides (Rienstra et al., 2002), and the first atomic resolution model of an amyloid fibril (Wasmer et al., 2008) have paved the way to high-resolution structural investigation of more complex protein complexes, including pathological amyloid aggregates (Schtz et al., 2015